Like Pasteur and the flask he made to trap the micro-organisms in the air. If it hadn't been for his flask, humans still might've believed that living organisms could appear spontaneaously out of no where. Pasteur boiled some broth in his special flask and proved that it didn't rot (=no organisms appeared from that boiled broth) unless some micro-organisms entered the flask.
And even statistics -- we have all these tests that help us prove if there are significant differences between groups. Apparently, we're supposed to hypothesize that there are no difference and do these tests to see if that hypothesis is wrong or not according to the data we have.
Coming from the humanities field, it really impresses me that humans could come up with all these ideas. It sort of reminds me that when I studied the constitution, I was impressed by the idea as much as I'm impressed with the T test now.
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